The Use and Safety of Umbilical Cord Stem Cells In Inflammatory Diseases, Wellness and Hair Regeneration

The goal in Regenerative Medicine is to “regenerate, repair and modify or slow down the progression of chronic disease by harnessing ones own body’s natural ability to heal itself.

The common denominator of chronic disease is inflammation. Inflammation causes heart disease,autoimmune disease, cancer and increases the aging process. Reducings inflammation is a key to improving health and slowing down the insidious progression of chronic disease.

Tmain function” o Mesenchymal Stem Cell (MSC) in adult tissue is to repair and regenerate the tissue

Currently, the FDA has registered dozens of clinical trials (phases 1–3) on the safety and efficacy of allogeneic unmodified UC-MSCs transplantation for the treatment of socially significant diseases including acute myocardial infarction, cardiomyopathies, critical limb ischemia, bronchopulmonary dysplasia in infants, HIV infection, diabetes mellitus types I and II, both acute and chronic liver diseases, autoimmune hepatitis, cirrhosis of various etiologies, ulcerative colitis, severe aplastic anemia, Alzheimer’s disease, systemic lupus erythematosus, rheumatoid arthritis, myelodysplastic syndrome, hereditary ataxia, spinal cord injury, ankylosing spondylitis, osteoarthritis, multiple sclerosis, Duchenne muscular dystrophy, acute and resistant to steroid therapy for “graft versus host” reactions, and other diseases.

MSC’s injected intravenously do not implant or become end-organ tissue, but lodge in the lung where they are activated to secrete anti-inflammatory protein (TSG-6) which is likely the anti-inflammatory factor that induces the beneficial effects in auto-immune inflammatory diseases.

If the infusion of stem cells with 50% probability can lead to changes of blood markers (50% is the maximum entropy), with 99.2% of probability it is reasonable to conclude that this treatment doesn’t lead to essential changes in blood markers and the stem cell treatment was safe for the patients.

Moreover, other studies have concluded that the use of umbilical cord is a source of MSCs that have no ethical problems with obtaining biomaterial, they have significant proliferative and differentiation potential, lack of tumorigenicity and have a high immunomodulatory activity.

Umbilical cord MSCs (UC-MSCs) for stem cell therapy has advantages over bone marrow MSCs (BM- MSCs) because they are easily available, collection from the donor is not invasive or painful, and there are no ethical considerations. In addition, UC-MSCs are a higher source of MSC than blood, bone marrow and adipose tissue.

Inflammation also causes hair loss in numerous autoimmune diseases like Alopecia Areata (AA), Discoid Lupus (DL) and Lichen Planopilaris (LPP) and is an important factor in male and female Androgenic Alopecia. Reducing systemic inflammation and reversing its harmful effects on end organ destruction is a key component in modifying disease and improving the symptoms of disease and general wellness.

Hair regenerative therapy with adipose derived stem cell infusion is effective for hair growth and is a potential alternative for hair regeneration in patients who are unwilling or unsuitable to undergo traditional surgical hair transplantation.

Our hair follicles are constantly recycling: when a hair falls out, a portion of the hair follicle has to grow back,which is an entirely stem cell-dependent process, but it turns out regulatory T cells (Tregs)are essential. If you knock out this one immune cell type, hair just doesn’t grow. Rregulatory T Cells (Tregs) a subpopulation of T cells which modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.

Studies show defects in Tregs could be responsible for alopecia areata, a common autoimmune disorder that causes hair loss and could potentially play a role in other forms of baldness, including male pattern baldness.

It is thought that immune cells come into a tissue to fight infection, while stem cells are there to regenerate the tissue after it’s damaged, But the reality is that stem cells and immune cells have to work together to make regeneration possible.

Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate humoral and cellular immune responses. Considering their regenerative potential and immunoregulatory effect, MSC therapy is a promising tool in the treatment of degenerative, inflammatory, and autoimmune diseases”. The reported side effects of increased hair growth, skin improvement, increased nail growth and wellness are all promising and warrant further review.

For more information please call our clinic @ (703) 992-9815
AUTHOR
Dr. Anteneh Roba

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